Suzhou nano-wearable sweat sensor research progress

Human sweat is rich in a host of potential health and disease-related markers that provide non-invasive and real-time continuous monitoring over conventional blood and urine testing, so wearable perspiration sensors Become one of the focuses in the field of wearable and healthy electronic devices. The miniaturized, all-solid-state, ion-selective electrode and the all-solid reference electrode are core sensing technologies for detecting electrolyte ion concentrations in perspiration. However, most of the existing solid-state ion sensors mostly use conductive polymers as the ion / electron conducting layer material, which has the disadvantages of poor stability, multiple interference factors and short service life, which limits its application in the field of wearable sweat detection.

Chinese Academy of Sciences Suzhou Institute of Nanotechnology and Nano-Bismuth Research Institute Zhang s? Core customers worry about the world market? , 1600404, 1-7, Back Cover). Furthermore, in view of the key scientific and technological issues such as the stability of the miniaturized solid-state ion sensor and the solid-state reference electrode, the research team designed and fabricated the electrode chip with the micropore array as the template by using the MEMS micro / nano processing technology, and prepared the electrode chip by one-step electrodeposition Compared with the ion / electron conducting layer based on carbon nanotubes, graphene and porous carbon, the three-dimensional gold nanostructured ion / electron conducting array electrode with large specific surface area and controllability has the advantages of simple preparation and good repeatability . The solid-state ion-selective electrode constructed by the electrode chip has stable potential response sensitivity (56.58 ± 1.02mV / decade), fast response time (<10s) and wide linear range (10-6-10-1mol / L) , The potential drift of the sensor and the influence of water layer interference are reduced.

By optimizing the composition of the reference electrode polymer film and salt, a polymer / potassium chloride based all-solid reference electrode is integrated on the sensor chip, and the obtained miniaturized reference electrode chip has the advantages of short equilibration time, And different ionic strength of the electrolyte interference response is small, insensitive to light, in the pH 3 ~ 10 range of response stability, with long-term stability and other advantages. At the same time, the research team innovatively designed wearable "sweat sweatband" sweat sensing devices with sweat collecting, transporting and discharging structures. The sensor chip and sweat sweat band are integrated and packaged, which can comfortably and conveniently wear on the forehead area , In the process of human movement of electrolyte ions in real-time continuous analysis and monitoring of people's health during exercise dehydration monitoring, especially for athletes, rescue workers, military personnel in the implementation of high-intensity tasks in the early warning of physical health status And instructive. Relevant research results published in Analytical Chemistry.

The work has been funded by the National Natural Science Foundation of China, the Outstanding Young Persons Fund of Jiangsu Province and the China Postdoctoral Science Foundation.

Figure 1 (A) Electrodeposition Preparation of different specific surface area of ​​three-dimensional gold nanostructured solid contact conductive array electrode; (B) All solid state ion selective array electrode structure diagram

Figure 2 (A), (B) and (C) are photographs and diagrams of wearable sweat sensor devices; (D) Calibration curves of sweat sensor chips before and after wearing on standard Na + solutions of different concentrations ; (E) is a continuous and continuous monitoring of the change of Na + concentration in sweat during the movement of the sweat sensor on the human body


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