Alcohol and coffee can affect longevity

Whenever our cells replicate in our bodies, the end point of the chromosomal DNA - called telomeres - replicates themselves to new cells, and each subsequent copy shortens until they can no longer keep the cells alive, resulting in their eventual death. However, a team of researchers collaborated with the Department of Molecular Microbiology Tel Aviv University (TAU) and Bravanica Institute of Biotechnology and Computer Science TAU and Columbia University Department of Life Sciences to study yeast shared important genetic similarities with humans. Their research results will surely refresh the drinkers in your life.

This is the first time that we have identified several environmental factors that change the length of telomeres. We have already demonstrated how they do this. We understand that one day it may contribute to the prevention and treatment of human diseases." Their findings in the journal PLoS Genetics.

Both yeast and alcohol, both of which are found, can effectively change the DNA linked to aging and cancer. A big shot of a shot of coffee and a distinct difference in the results of a single beer. Drinking coffee will hype you, and a frosty brewing can help you relax. And these drinks, this group said, may also have the opposite effect on your genome. As mentioned above, telomeres - by DNA and protein - shorten the time for each replication. Only fetuses and tumor cells have different behaviors. Both types of cells can reproduce eternal.

This latest study builds on the 2004 study by Elizabeth Blackburn, the Nobel Prize winner in economics and a molecular biologist. Blackburn's research shows that emotional stress may lead to shortening of telomeres. After stress and subsequent telomere shortening, the aging properties produce free radicals in the cell, Blake speculated. The Saccharomyces cerevisiae growing by the bull-headed team caused cells to rupture in order to produce free radicals. They wanted to test the effect on telomere length and were surprised to learn that there was no change in telomere length.

From this point of view, the team exposed Yeast 12 to other environmental pressures. They found that most pressures - such as variances in temperature and pH from certain substances and chemicals - have no effect on the length of telomeres. However, they found that shortened telomeres were low levels while ethanol extended them.

In short, the team scanned 6,000 strains of yeast and disabled a different gene in each one. They found that two genes, Rap1 and RIF1, are essential in mediating environmental stress and telomere length. Genes from nearly 400 individuals work together to maintain telomere length. In this regard, the researchers said that the need for this gene network to maintain the stability of the genome, and its role in further research. Also interesting is that most of the yeast genes are also present in the human genome.

This is the first time someone has analyzed a complex system and all the genes that affect it are known. It turns out that the telomere length thing is very accurate, which shows that accuracy is crucial and should be protected from the environment. At this point, the study demonstrated only a correlation between telomere length and aging or cancer. The team further acknowledges that laboratory work requires the establishment of a causal relationship. This work will show whether human telomeres respond to the same signal as yeast. If they do this, because the team thinks they will, scientists will use the findings to develop physical therapy and dietary guidance.

Marine Spud

The spud is main part Cutter Suction Dredger, when operation, through steel spud

Cross-cut construction method

1, the cutter suction Dredger is equipped with spud in the general area of construction, steel spud should be symmetrical cross-cut method or a steel cross-car spud digging method of construction.

2, in the area of large waves, equipped with three cable dredger positioning spud should be positioned with three cable cross-cut construction method.

3, the flow velocity in large areas or large waves, equipped with an anchor on the cable cross digging equipment cutter suction dredger, anchor cable should be used cross-cut construction method

Segment dig method

1, Trench length greater than the length of the water pipeline dredge effective extension should be segmented according to the length of the dredgers and the construction of water pipelines can Excavation.

2. Trench turnaround curve is divided into several sections require excavation of straight line segments can be linear piecewise curve approximation safe construction.

3. Trench different specifications or different schedule requirements, should be in accordance with the requirements of the contract segment.

4, navigation or interference by other factors, the construction can be segmented as needed

Shun countercurrent construction

When river construction using steel spud positioned, should adopt the downstream construction; construction should be used when using countercurrent anchor cable cross-dig construction method; when the large flow rates, and can be used under construction downstream end of the anchor to ensure safety.

Photo of our Marine Spud:

The specifications of our spud

A. General

High accuracy, fully welded, painted construction can be used for cutter suction dredger.

When the cutter suction dredger is working, two spuds insert the sea alternatively, one is main pile, always aligned pocket centerline and the other is vice pile used forward exchange, to meet dredger back and forth and meet dredging work.

B. Construction and procedure

The construction is to be built according to the drawing with rules of good workmanship and to be built the longitudinal frame system.

The construction is of rolled Steel Pipe sections with varying wall thickness, from40mm to 150mm, which are carefully manufactured and checked to ensure roundness, straightness, segment connection deflection within the specific tolerances.

C. Procedure

Pre-roll bending pf plate-Rolling of cylindrical hull-Welding the vertical seam to close the section-Heat treatment-Rolling to correct ovality-Assemble of the several pipe sections-Assemble with accessories( Sheave , expansion part etc.)

D. Materials

All fabricated steelwork used in the construction of the spud will be to manufacturing standard of classification society BV, GL, LR, DNV

All steel used to be blasted and shop primed both sides. Using DH36 and D690

All materials proposed will be selected to comply with the latest Health and Safety Rules.

Paint systems for hull protection will be of the highest quality (Hempel, Inter, Sigma, Jotun)

E. Welding

All welding will be performed in accordance with drawing and order and UniSite experience and all welding will be continuous and full penetration.

Welding seam preparation, welding method, welding material and consequent preheating temperature acc. to UniSite standards and approved by clients.

UniSite will control preheating, cooling down rate

Weld surface on the outside spud surface are to be grinded flush.

All welding to be examined UT and some to be examined X-ray.

F. Workmanship

The workmanship have good marine practice. Care are taken to ensure fair lines, smooth surfaces and neat welding.

G. Main particulars

High Quality Dredge Spud,Customized Dredge Spud,Customized Weld Spud,Marine Dredge Spud

Unisite Group Ltd. , https://www.shipsparts.nl